Reference Design For Glucometer

Powered by the Flexis MM microcontroller household, transforms glucose monitoring by way of precision engineering and progressive design. 

The regulation of blood glucose ranges is a finely tuned course of within the human physique, primarily ruled by two hormones produced by the pancreas: insulin and glucagon. Insulin, secreted by beta cells, is launched in response to elevated blood glucose ranges, whereas glucagon, produced by alpha cells, is secreted when blood glucose ranges are low. This delicate steadiness is essential for sustaining metabolic homeostasis. Nevertheless, disruptions on this system can result in diabetes, a persistent situation characterised by irregular blood glucose ranges. Diabetes arises when the pancreas fails to provide enough insulin or when the physique’s cells turn into proof against insulin’s results.

To deal with the necessity for correct glucose monitoring, this reference design AN4364 by NXP Semiconductor introduces a glucometer, known as MED-GLU. The gadget leverages superior microcontroller know-how to make sure exact glucose measurement. It’s carried out utilizing the Freescale MCU Kinetis K53, a MCF51MM, or an S08MM128, all a part of the Flexis MM household. These microcontrollers boast options optimized for medical purposes. The Kinetis K53, as an illustration, consists of an ultra-low-power operation mode, two operational amplifiers (OPAMP), two transimpedance amplifiers (TRIAMP), two 12-bit digital-to-analog converters (DAC), and two 16-bit SAR analog-to-digital converters (ADC) with as much as 31 channels and programmable acquire amplifiers (PGA). Further options embody an inter-integrated circuit (I2C), USB connectivity, and an ARM Cortex M4 core with digital sign processor (DSP) directions.

– Commercial –

Equally, the MCF51MM and S08MM128 microcontrollers present ultra-low-power operation, two OPAMPs, two TRIAMPs, a 16-bit SAR ADC with 4 differential channels and as much as 12 exterior single-ended channels, a 12-bit DAC, I2C, USB connectivity, and a multiply-accumulate (MAC) unit obtainable within the MCF51MM. These microcontrollers are constructed on ColdFire V1 and HCS08 cores, respectively. The glucometer’s implementation requires further exterior elements built-in into an Analog Entrance Finish (AFE). A essential facet of the system includes the usage of glucose oxidase enzyme to catalyze a response between glucose and oxygen, resulting in a change in pH, oxygen partial stress, and hydrogen peroxide ranges as a result of glucose oxidation. The output generated by the take a look at strip on this response is a present proportional to glucose focus.

The present is transformed to a voltage utilizing a current-to-voltage converter to course of this sign. This conversion depends on the TRIAMP embedded within the Kinetis K53, which contains a single provide, low-input offset voltage, low-input offset and bias present, and an exterior suggestions resistor. The ensuing voltage sign undergoes filtering and therapy to make sure exact glucose measurement, forming the premise of an environment friendly and dependable glucometer design.

– Commercial –

NXP Semiconductor assessments it, together with system block diagrams, schematics, and PCB design information. This ensures customers have entry to all mandatory assets for implementing, evaluating, and customising the answer. It contains a sturdy energy system primarily based on high-performance elements, making certain reliability and effectivity.For extra data, click on right here.